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There is an increased risk of heart attack, heart failure, and stroke cant take ibuprofen taking nonsteroidal anti-inflammatory drugs NSAIDs these events may occur at any time during treatment and risk increases with long term use, a history of cardiovascular CV disease or risk factors for CV disease, and higher doses.

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Systemic lupus erythematosus as well as those with why cant i take ibuprofen connective tissue disease increased risk of aseptic meningitis see section 4. Renal impairment as renal function may further deteriorate see sections 4.Experimental data suggest that ibuprofen may competitively inhibit the effect of low dose aspirin acetylsalicylic acid on platelet aggregation when they are dosed concomitantly.

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