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Clinical data
Pronunciation/ b j uː ˈ p r oʊ p i ɒ n / bew- PROH -pee-on
Trade namesWellbutrin, Zyban, others
License dataUS   FDA: Bupropion
Pregnancy categoryAU: B2 US: C (Risk not ruled out)
Dependence liabilityNone to very low
Addiction liabilityNone to very low
Routes of administrationMedical: by mouth Recreational: by mouth, insufflation, intravenous
ATC codeN06AX12 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Protein binding84% (bupropion), 77% (hydroxybupropion metabolite), 42% (threohydrobupropion metabolite) [2]
MetabolismLiver (mostly CYP2B6-mediated hydroxylation, but with some contributions from CYP1A2, CYP2A6, CYP2C9, CYP3A4, CYP2E1 and CYP2C19) [2] [3] [4] [5]
Elimination half-life12–30 hours [4] [6]
ExcretionRenal (87%; 0.5% unchanged), faecal (10%) [2] [3] [4]
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Wellbutrin SR / Wellbutrin XL. (bupropion). Xanax (alprazolam). Zoloft (sertraline) . W. ER. Zyprexa (olanzapine). Other: Past Psychiatric History.: Untitled - UAB

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our of every 1000 persons who receive Wellbutrin in doses less than 450 mg/day experience seizures.

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This medication helped my ADD for years.n the other hand, sudden withdrawal from alcohol following regular or chronic use can also increase your risk of seizures during treatment with buPROPion. f you are prone to frequent or excessive alcohol use, talk to your doctor before starting buPROPion.

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Judge R, Discontinuation symptoms: trintellix and wellbutrin combo of brief interruption in fluoxetine and paroxetine treatment.he dose for seasonal affective disorder is 150 mg trintellix and wellbutrin combo daily up to 300 mg daily using bupropion hydrochloride extended release tablets for example, Wellbutrin XL Alternatively, treatment may be started with 174 mg bupropion hydrobromide Aplenzin daily and increased to a target dose of 348 mg day.


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