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All-trans-retinoic acid (ATRA, tretinoin ); Arsenic trioxide (ATO). ATRA is a form of vitamin A that is typically part of the initial treatment of APL.

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    The importance of retinol vitamin A was discovered during World War I and subsequent research showed that its deficiency gives rise to xerosis and follicular hyperkeratosis.It is also not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity.

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