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Tacrolimus
Clinical data
Trade namesPrograf, Advagraf, Protopic, others
AHFS/Drugs.comMonograph
License dataEU  EMA:  by INN
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationTopical, oral, iv
ATC codeD11AH01 ( WHO ) L04AD02 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability24% (5–67%), less after eating food rich in fat
Protein binding≥98.8%
MetabolismHepatic CYP3A4, CYP3A5
Elimination half-life11.3 h for transplant patients (range 3.5–40.6 h)
ExcretionMostly faecal

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Tacrolimus all other nameprotopic
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Tacrolimus is an immunosuppressant.Use the smallest amount of PROTOPIC Ointment needed to control the signs and symptoms ofeczema. If you are limustin tacrolimus precio caregiver applying PROTOPIC Ointment to a patient, or if you are a patient who isnot treating your hands, wash your hands with soap and water after applying PROTOPIC.

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ROGRAF tacrolimus capsules, for oral usePROGRAF tacrolimus injection, for intravenous usePROGRAF Granules tacrolimus for oral suspension nitial U. Approval: 1994PROGRAF is a calcineurin-inhibitor immunosuppressant indicated for the prophylaxis of organ rejection in adult and pediatric patients receiving allogeneic liver, kidney or heart transplants, in combination with other immunosuppressants.

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