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Am J Respir Cell Mol Biol.3 m2 However, pitavastatin and pravastatin undergo renal and hepatic elimination, with renal excretion reaching 15 and 20-47% of the administered dose, respectively.

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5 Thus, the net benefit among high risk patients in need of statins favours their use, consistent with the Joint Task Force guidelines recommendations. These data are consistent with findings among patients with DM treated with statins who derive a similar relative risk RR reduction per unit reduction in LDL-C but a greater absolute benefit.The use of a claims database minimized the possibility of recall bias for drug use.

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JAMA.2. Recommended starting dose for patients at high risk of CHD is 40 mg/day.

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ISBN 978-1-4665-1679-3. "Simvastatin Prices, Coupons Patient Assistance Programs".In patients taking amiodarone, amlodipine, verapamil or diltiazem concomitantly with simvastatin, the dose of simvastatin should not exceed 20 mg/day. See sections 4.

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