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Paracetamol
Clinical data
PronunciationParacetamol: / ˌ p ær ə ˈ s iː t ə m ɒ l / Acetaminophen: / ə ˌ s iː t ə ˈ m ɪ n ə f ɪ n / ( listen )
Trade namesTylenol, Panadol, others [2]
AHFS/Drugs.comMonograph
MedlinePlusa681004
License dataUS   FDA: Acetaminophen
Pregnancy categoryAU: A US: C (Risk not ruled out) [1] Not tested but seems to be safe
Routes of administrationBy mouth, through the cheek, rectal, intravenous (IV)
ATC codeN02BE01 ( WHO )
Legal status
Legal statusAU: S4 (Rx), OTC, and unscheduled UK: General sales list (GSL, OTC) US: OTC
Pharmacokinetic data
Bioavailability63–89% [4] : 73
Protein binding10–25% [5]
MetabolismPredominantly in the liver [3]
MetabolitesAPAP gluc, APAP sulfate, APAP GSH, APAP cys, NAPQI [6]
Onset of actionPain relief onset by route: By mouth – 37 minutes [7] Buccal – 15 minutes [7] Intravenous – 8 minutes [7]
Elimination half-life1–4 hours [3]
ExcretionUrine (85–90%) [3]

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Full Text. US Food and Drug Administration.Advise both patients and acetaminophen and cymbalta about the risks of respiratory depression and sedation when Acetaminophen and Codeine Phosphate Tablets are used with benzodiazepines or other CNS depressants including alcohol and illicit drugs Advise patients not to drive or operate heavy machinery until the effects of concomitant use of the benzodiazepine or other CNS depressant have been determined.

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Isks are increased tylenol and cymbalta patients with a personal or family history of substance abuse including drug or alcohol abuse or addiction or mental illness e. major depression The potential for these risks should not, however, prevent the proper management of pain in any given patient.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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To 210 compared with sumatriptan 100 mg.If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2020 Cerner Multum, Inc.

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It is not known whether these effects on fertility are reversible. Inform patients that acetaminophen and codeine phosphate tablets may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery and to avoid such tasks while taking this product, until they know how they will react to the medication.Jaeschke Tylenol and cymbalta, Akakpo JY, Umbaugh DS, Ramachandran A.

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