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There is no evidence from controlled studies that Selegiline has any beneficial effect in the absence of concurrent levodopa therapy. Evidence supporting this claim was obtained in randomized controlled clinical investigations that compared the effects of added Selegiline or placebo in patients receiving levodopa/carbidopa. Doug Ziedonis, MD: NIDA – “Phase 2, Double-Blind, Placebo Controlled Trial of Selegiline.

Transdermal System as an Aid for Smoking Cessation”; 10/24/06; .. Other serious reactions including severe agitation, hallucinations, and death have been reported in patients receiving this combination see CONTRAINDICATIONS Severe toxicity has also been reported in patients receiving the combination of tricyclic antidepressants and selegiline and selective serotonin re-uptake inhibitors and selegiline ‒ anovenydoki.hu.

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In the pool of short-term major depressive disorder trials, 9. of EMSAM-treated patients and 6.Transdermal selegiline is contraindicated for use in children younger than 12 years and in patients of any age who have pheochromocytoma.

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Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised.epression and other serious mental illnesses are the most important causes of suicidal thoughts and actions.

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