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Clinical data
Pronunciation/ ˌ m ɛ t ə ˈ k l ɒ p r ə m aɪ d /
Trade namesPrimperan, Reglan, others [1]
License dataUS   FDA: Metoclopramide
Pregnancy categoryAU: A US: B (No risk in non-human studies)
Routes of administrationBy mouth, intravenous, intramuscular
Drug classD 2 receptor antagonist; 5-HT 3 receptor antagonist; 5-HT 4 receptor agonist; Prolactin releaser
ATC codeA03FA01 ( WHO )
Legal status
Legal statusAU: S3 (combination with paracetamol), S4 (alone) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability80 ± 15% (by mouth)
Elimination half-life5–6 hours
ExcretionUrine: 70–85% Feces: 2%

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5. Which of the following would you do? A. Stop the metoclopramide (eg. Reglan ). B. Stop the prochlorperazine. (Compazine). C. Stop the valproate (Depakote).

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    When a reglan for diarrhea has low prolactin levels, milk supply may be affected. Prolactin levels are primarily regulated by inhibition: the presence of prolactin-inhibiting factors dopamine is the principal one keep prolactin levels in check.Convulsive seizures have been reported, especially in patients with epilepsy; however, there is no obvious association with use of this drug.

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    This is not a complete reglan for diarrhea of side effects and others may occur. Call your doctor for medical advice about side effects.Data from patients receiving large IV doses of metoclopramide 8 mg/kg in 4 divided doses for the reglan for diarrhea of cisplatin-induced nausea and vomiting indicate that serum metoclopramide concentrations greater than 850 ng/mL may be required for optimum antiemetic effect in patients receiving cisplatin.

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