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A synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, nicardipine ( Nifedipine Family) blocks calcium ions from certain cell walls and ...:
Definition of nicardipine - NCI Drug Dictionary - National ...
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Nifedipine. chemical structure image · KCNC1 Tclin IC. : 3.9. Active Ligands (4). help. 1 – 4 of 4. cromakalim. chemical structure image · KCNC1 Tclin IC. : 3.6.
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Mylan nifedipine er n vitro drug interaction studies have demonstrated that quinupristin/dalfopristin significantly inhibits the CYP3A metabolism of nifedipine.Nifedipine has been shown to inhibit the formation of oxidized metabolites of irbesartan in vitro; however, concomitant nifedipine therapy had no effect on irbesartan pharmacokinetics in clinical studies.
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Following mylan nifedipine er administration of nifedipine, such prehepatic inhibition of drug metabolism by grapefruit juice appears mainly to involve the CYP3A4 isoenzyme, principally within the wall of the small intestine e. in the jejunum thus increasing systemic availability of the drug.The mechanism of this effect is not established.
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