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Enyon S, Boulvain M, Neilson JP. Antibiotics for preterm rupture of membranes.Among women with PPROM, antibiotics may reduce the risk of preterm birth within 48 hours of administration, but little evidence of benefit exists for other outcomes.
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If an adequate blood pressure response is not achieved with nifedipine monotherapy, another antihypertensive agent with demonstrated mylan nifedipine er may be added; if goal blood pressure is still mylan nifedipine er achieved with the use of 2 antihypertensive agents at optimal mylan nifedipine er, a third drug may be added.
In patients who experience intolerable adverse effects with nifedipine, dosage reduction should be considered; if adverse effects worsen or fail to resolve, it may be necessary to discontinue the calcium-channel blocker and switch to another class of antihypertensive agent.Caution should be exercised when coadministering diltiazem and nifedipine and a reduction of the dose of nifedipine should be considered.
Verapamil: Verapamil, a CYP3A inhibitor, can inhibit the metabolism of nifedipine and increase the exposure to nifedipine during concomitant therapy.
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Nifedipine is a calcium channel blocker that is used to treat hypertension high blood pressure mylan nifedipine er 30 mg angina chest pain Nifedipine may also be used for purposes not listed in this medication guide.revious studies have also shown that calcium channel blockers were effective, but this review expands the research for this indication and might inform future guidelines. Major outcomes considered included frequency and severity of attacks, pain, quality of life, withdrawals and serious adverse events.
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World J Gastrointest Surg. 2019 Mar. 117-21.Calcium-channel blockers may be particularly useful in the management of hypertension in black patients; these patients tend to have greater blood pressure response to calcium-channel blockers and thiazide diuretics mylan nifedipine er to other antihypertensive drug classes e.
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In patients who underwent transplantation and received such concomitant therapy, tacrolimus dosage reductions of 26-38% were required; tacrolimus blood concentrations should be monitored, and a reduction in tacrolimus dosage should be considered in these patients.but less than 16.
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While calcium-channel blockers appear to have a good maternal and fetal safety profile, most studies on tocolytic drugs have primarily focused on otherwise low-risk pregnancies.Rhoades R, Planzer R.
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Circulation. R. PubMed CrossRef Google Scholar Zanchetti A. Rosei E. A. Dal Palu C. Leonetti G. Magnani B. Pessina A. 1998 The Verapamil in Hypertension and Atherosclerosis Study VHAS results of long-term randomized treatment with either verapamil or chlorthalidone on carotid intima-media mylan nifedipine er moderate decrease in platelet aggregation and increases in bleeding time, believed to be related to inhibition of calcium transport across the platelet membrane, have been reported in patients receiving nifedipine in a limited number of clinical studies; however, these findings were not considered to be clinically important.
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Medline.diltiazem, verapamil also were associated with increased risk of myocardial infarction in the described case-control study, results of previous well-designed clinical studies indicate that the use of calcium-channel blocking agents was not associated with an increased risk mylan nifedipine er 30 mg death; therefore, the adverse effects associated with short-acting nifedipine may not necessarily apply to other calcium-channel blocking agents, including other short-acting dihydropyridines e.
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