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Clinical data
PronunciationParacetamol: / ˌ p ær ə ˈ s iː t ə m ɒ l / Acetaminophen: / ə ˌ s iː t ə ˈ m ɪ n ə f ɪ n / ( listen )
Trade namesTylenol, Panadol, others [2]
License dataUS   FDA: Acetaminophen
Pregnancy categoryAU: A US: C (Risk not ruled out) [1] Not tested but seems to be safe
Routes of administrationBy mouth, through the cheek, rectal, intravenous (IV)
ATC codeN02BE01 ( WHO )
Legal status
Legal statusAU: S4 (Rx), OTC, and unscheduled UK: General sales list (GSL, OTC) US: OTC
Pharmacokinetic data
Bioavailability63–89% [4] : 73
Protein binding10–25% [5]
MetabolismPredominantly in the liver [3]
MetabolitesAPAP gluc, APAP sulfate, APAP GSH, APAP cys, NAPQI [6]
Onset of actionPain relief onset by route: By mouth – 37 minutes [7] Buccal – 15 minutes [7] Intravenous – 8 minutes [7]
Elimination half-life1–4 hours [3]
ExcretionUrine (85–90%) [3]

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Los s ntomas de sobredosis pueden ser: mareos, v mitos, p rdida de apetito, coloraci n amarillenta de la piel y los ojos ictericia y dolor abdominal. Si ha ingerido una sobredosis, debe acudir inmediatamente a un centro m dico aunque no effect of paracetamol on kidney los s ntomas, ya que a menudo stos no se manifiestan hasta pasados 3 d as desde la ingesti n de la sobredosis, incluso en casos de intoxicaci n grave.For chewable tablets, chew thoroughly before swallowing.

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It is possible for one person to have both osteoarthritis and osteoporosis. The paracetamol effects on kidneys in the signs and symptoms of osteoarthritis and osteoporosis include; pain, stiffness, and joint swelling, joint deformity, crackle sounds when the joint is moving, and walking with a limp.All NSAIDS are associated with a risk of GI, cardiovascular, and kidney adverse effects, some more than others.

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