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|Pronunciation||Paracetamol: / ˌ p ær ə ˈ s iː t ə m ɒ l / Acetaminophen: / ə ˌ s iː t ə ˈ m ɪ n ə f ɪ n / ( listen )|
|Trade names||Tylenol, Panadol, others |
|License data||US FDA: Acetaminophen|
|Pregnancy category||AU: A US: C (Risk not ruled out)  Not tested but seems to be safe|
|Routes of administration||By mouth, through the cheek, rectal, intravenous (IV)|
|ATC code||N02BE01 ( WHO )|
|Legal status||AU: S4 (Rx), OTC, and unscheduled UK: General sales list (GSL, OTC) US: OTC|
|Bioavailability||63–89%  : 73|
|Protein binding||10–25% |
|Metabolism||Predominantly in the liver |
|Metabolites||APAP gluc, APAP sulfate, APAP GSH, APAP cys, NAPQI |
|Onset of action||Pain relief onset by route: By mouth – 37 minutes  Buccal – 15 minutes  Intravenous – 8 minutes |
|Elimination half-life||1–4 hours |
|Excretion||Urine (85–90%) |
2003 Apr; 4 405-12. doi. 365. Cochrane Database Syst Rev. 2013 Dec 12; 12 CD004624. doi.
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Abstract Antipyretics, including acetaminophen ( paracetamol ), are prescribed commonly in children with pyrexia, despite minimal evidence of a clinical benefit.:
Evidence on the use of paracetamol in febrile children
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