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Primidone
Clinical data
Trade namesLepsiral, Mysoline, Resimatil, Primaclone
AHFS/Drugs.comMonograph
Pregnancy categoryUS: D (Evidence of risk)
Dependence liabilityModerate-high [ medical citation needed ]
Routes of administrationOral
ATC codeN03AA03 ( WHO )
Legal status
Legal statusUK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability~100% [1]
Protein binding25% [1]
MetabolismHepatic
Elimination half-lifePrimidone: 5-18 h, Phenobarbital: 75-120 h, [1] PEMA: 16 h [2] Time to reach steady state: Primidone: 2-3 days, Phenobarbital&PEMA 1-4weeks [3]
ExcretionRenal

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