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Clinical data
Pronunciation/ ˈ aɪ b juː p r oʊ f ɛ n /, / aɪ b juː ˈ p r oʊ f ən /, EYE -bew- PROH -fən
Trade namesAdvil, Motrin, Nurofen, others
License dataEU  EMA:  by INN, US   FDA: Ibuprofen
Pregnancy categoryAU: C US: C (Risk not ruled out) D (US) at ≥30 weeks of gestation, due to the potential for premature closure of the ductus arteriosus
Routes of administrationby mouth, rectal, topical, and intravenous
ATC codeC01EB16 ( WHO ) G02CC01 ( WHO ) M01AE01 ( WHO ) M02AA13 ( WHO ) R02AX02 ( WHO )
Legal status
Legal statusAU: OTC CA : OTC UK: General sales list (GSL, OTC) US: OTC (R x -only at higher doses)
Pharmacokinetic data
Bioavailability80–100% (by mouth), [2] 87% (rectal)
Protein binding98% [1]
MetabolismLiver (CYP2C9) [1]
Metabolitesibuprofen glucuronide, 2-hydroxyibuprofen, 3-hydroxyibuprofen, carboxy-ibuprofen, 1-hydroxyibuprofen
Onset of action30 min [3]
Elimination half-life2–4 h [4]
ExcretionUrine (95%) [1] [5]

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The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. 1Department of Anesthesiology, The Ohio State University Wexner Medical Center, Columbus, OH, United States 2Department of Orthopedics, Jameson Crane Sports Medicine Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United States 3Center of Biostatistics, The Ohio State University, Columbus, OH, United States 4Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, United States Introduction: Acute postoperative pain liquid ibuprofen walmart knee arthroscopy is common in liquid ibuprofen walmart surgeries.Although the liquid ibuprofen walmart mechanisms have not been clearly established, NSAIAs appear to exert anti-inflammatory, analgesic, and antipyretic activity principally through inhibition of the COX-2 isoenzyme; COX-1 inhibition presumably is responsible for the drugs' unwanted effects on GI mucosa and platelet aggregation.

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