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Metoprolol
Clinical data
Pronunciation/ m ɛ ˈ t oʊ p r oʊ l ɑː l /, / m ɛ t oʊ ˈ p r oʊ l ɑː l /
Trade namesLopressor, Metolar XR, others
AHFS/Drugs.comMonograph
MedlinePlusa682864
License dataUS   FDA: Metoprolol
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth, IV
Drug classBeta blocker
ATC codeC07AB02 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability50% (single dose) [1] 70% (repeated administration) [2]
Protein binding12%
MetabolismLiver via CYP2D6, CYP3A4
Elimination half-life3–7 hours
ExcretionKidney

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The 12-lead ECG shows sinus arrest and junctional escape beats of 36 beats/minute with QRS width of 93 ms. The 4th QRS complex is thought of as a sinus beat with the preceding P wave.da.

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Authorship Information: Concept and ic metoprolol succ er 25 mg tab SC, ES, JJ, EO, CK, JX, EW acquisition of data ES, JJ, EO, EW analysis and interpretation of data SC, ES, JJ, EO, CK, JX, EW drafting of the ic metoprolol succ er 25 mg tab ES, JJ, EO, CK critical revision of the manuscript for important intellectual content SC, ES, JJ, CK, JX, EW statistical analysis SC, ES, JJ, EO, CK, EW obtaining funding SC administrative, technical, or logistic support SC, EO supervision SC, JX Address correspondence to: Elyse Swallow, Analysis Group, 111 Huntington Ave, 10th Fl, Boston, MA 02199.

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