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3729. Epub 2008 May 2.

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If the drugs are administered separately in the treatment of heart failure, an initial dosage of isosorbide dinitrate 20-30 mg 3 or 4 times daily, given concomitantly with hydralazine hydrochloride 25-50 mg 3 or 4 times daily, is recommended by the American College of Cardiology Foundation ACCF and American Heart Association AHA Dosages of the drugs should be titrated to levels similar to those isosorbide m for the fixed-combination preparation and administered at least 3 times daily.No effects isosorbide m fertility were observed in a study in which male and female rats were administered doses of up to 750 mg/kg/day beginning, in males, 9 weeks prior to mating, and in females, 2 weeks prior to mating.

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Nitrate therapy may aggravate the angina caused by hypertrophic cardiomyopathy, particularly in the elderly. The table below shows the frequencies of the adverse events that occurred in 5% of the subjects in three placebo-controlled North American studies, in isosorbide mono er patients in the isosorbide mono er treatment arm received 30 mg, 60 mg, 120 mg, or 240 mg of ISMN as Isosorbide mononitrate extended-release tablets once daily.View feedback from our existing customers.

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It is unknown if this medication defines mononitrate into breast milk. Consult your doctor before breast-feeding.Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

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Or oral administration. ethod of administrationThe tablet should be swallowed whole, taken after meals.Do not take other medicines unless they have been discussed with your doctor. This includes prescription or isosorbide m over-the-counterOTC medicines and isosorbide m or vitamin supplements.

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He metabolites are excreted mainly via the kidneys. nly about 2% of the dose given is excreted intact via the kidneys.to 4.

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A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.The relative importance of preload reduction, afterload reduction, and coronary dilatation remains undefined.

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In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac The ill isosorbide mononit er 30 mg tb of isosorbide dinitrate overdose are generally the results of isosorbide dinitrate s capacity to induce vasodilatation, venous pooling, reduced cardiac output, and hypotension.

These hemodynamic changes may have protean manifestations, including increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; vertigo; palpitations; visual disturbances; nausea and vomiting possibly with colic and even bloody diarrhea syncope especially in the upright posture air hunger and dyspnea, later followed by reduced ventilatory effort; diaphoresis, with the skin either flushed or cold and clammy; heart block and bradycardia; paralysis; Laboratory determinations of serum levels of isosorbide dinitrate and its metabolites are not widely available, and such determinations have, in any event, no established role in the management of There are no data suggesting what dose of isosorbide dinitrate is likely to be life-threatening in humans.In case of signals of a respiratory and circulatory arrest, start reanimation immediately.



. FDA (September.


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