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Upon exposure to stimuli, NF- B is activated either through canonical or noncanonical pathways by regulatory I B kinases IKK such as IKK, IKK, and IKK. In the ashwagandha root extract vs powder common classical pathway, IKK phosphorylation leads to I B phosphorylation at serine 32 and serine 36, followed by phosphorylation, nuclear localization, DNA binding of p65 p50 complex, and transcriptional activation of NF- B responsive genes104.Stress can cause lethargy and disturbed sleep.
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