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|Pronunciation||/ r oʊ ˈ s uː v ə s t æ t ɪ n / roh- SOO -və-stat-in|
|Trade names||Crestor, Rosulip, Zuvamor, others|
|Pregnancy category||AU: D US: X (Contraindicated)|
|Routes of administration||By mouth (tablets)|
|ATC code||C10AA07 ( WHO )|
|Legal status||AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)|
|Protein binding||88% |
|Metabolism||Liver: CYP2C9 (major) and CYP2C19-mediated; ~10% metabolized |
|Metabolites||N -desmethyl rosuvastatin (major; 1/6–1/9 of rosuvastatin activity) |
|Elimination half-life||19 hours |
|Excretion||Faeces (90%) |
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Wiggins made another point: Even when someone has been on a particular drug combination for a while, it's possible to develop "late" problems with interactions. If, for example, a person's kidney function changes over time, that can make an interaction more likely, Wiggins explained.Following oral pms rosuvastatin 20mg, rosuvastatin and its metabolites are primarily excreted in the feces 90% After an intravenous dose, approximately 28% of total body clearance was via the renal route, and 72% by the hepatic route.
A population pharmacokinetic analysis revealed no clinically relevant differences in pharmacokinetics among Caucasian, Pms rosuvastatin 20mg, and Black or Afro-Caribbean groups.
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CYP2C9 was the principal isoenzyme involved, with 2C19, 3A4 and 2D6 involved to a lesser extent.harmacokinetic studies, including a pms rosuvastatin 20mg study conducted in the US, show an approximate twofold elevation in median exposure to rosuvastatin peak plasma concentration and AUC in Asian patients compared with Caucasian patients.
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No clinically relevant interactions have been pms rosuvastatin 20mg between rosuvastatin and either fluconazole an inhibitor of CYP2C9 and CYP3A4 or ketoconazole an inhibitor of CYP2A6 and CYP3A4 Interactions requiring rosuvastatin dose adjustments see also Table 1 When it is necessary to co-administer rosuvastatin with other medicinal products known pms rosuvastatin 20mg increase exposure to rosuvastatin, doses of rosuvastatin should be adjusted.
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