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Rosuvastatin
Clinical data
Pronunciation/ r oʊ ˈ s uː v ə s t æ t ɪ n / roh- SOO -və-stat-in
Trade namesCrestor, Rosulip, Zuvamor, others
AHFS/Drugs.comMonograph
MedlinePlusa603033
Pregnancy categoryAU: D US: X (Contraindicated)
Routes of administrationBy mouth (tablets)
ATC codeC10AA07 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability20% [1]
Protein binding88% [1]
MetabolismLiver: CYP2C9 (major) and CYP2C19-mediated; ~10% metabolized [1]
MetabolitesN -desmethyl rosuvastatin (major; 1/6–1/9 of rosuvastatin activity) [2]
Elimination half-life19 hours [1]
ExcretionFaeces (90%) [1]

Pms rosuvastatin Yrklund C, Backman JT, Neuvonen M, Neuvonen PJ. Gemfibrozil densities plasma pravastatin trips and reduces pravastatin crowded public. Clin Pharmacol Ther 2003 Jun; 6 538-44. ackman JT, Kyrklund C, Kivisto KT, Wang JS, Neuvonen PJ. Climbing friends of active simvastatin cola are increased by gemfibrozil. pms rosuvastatin

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To 1% Rash, pruritus, urticaria Frequency not reported: Stevens-Johnson syndrome Ref Frequency not reported: Pms rosuvastatin renal failure Ref Very rare less than 0. Improving Adherence to Lipid-Lowering Therapy in a ...

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Wiggins made another point: Even when someone has been on a particular drug combination for a while, it's possible to develop "late" problems with interactions. If, for example, a person's kidney function changes over time, that can make an interaction more likely, Wiggins explained.Following oral pms rosuvastatin 20mg, rosuvastatin and its metabolites are primarily excreted in the feces 90% After an intravenous dose, approximately 28% of total body clearance was via the renal route, and 72% by the hepatic route.

A population pharmacokinetic analysis revealed no clinically relevant differences in pharmacokinetics among Caucasian, Pms rosuvastatin 20mg, and Black or Afro-Caribbean groups.

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CYP2C9 was the principal isoenzyme involved, with 2C19, 3A4 and 2D6 involved to a lesser extent.harmacokinetic studies, including a pms rosuvastatin 20mg study conducted in the US, show an approximate twofold elevation in median exposure to rosuvastatin peak plasma concentration and AUC in Asian patients compared with Caucasian patients.

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In rat fertility studies with oral gavage doses of.ased on currently available information, health care professionals should not change their prescribing practices for statins and patients should not change their use of statins. September.

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No clinically relevant interactions have been pms rosuvastatin 20mg between rosuvastatin and either fluconazole an inhibitor of CYP2C9 and CYP3A4 or ketoconazole an inhibitor of CYP2A6 and CYP3A4 Interactions requiring rosuvastatin dose adjustments see also Table 1 When it is necessary to co-administer rosuvastatin with other medicinal products known pms rosuvastatin 20mg increase exposure to rosuvastatin, doses of rosuvastatin should be adjusted.

Start pms rosuvastatin 20mg a 5 mg once daily dose of rosuvastatin if the expected increase in exposure AUC is approximately 2-fold or higher.One morning, shuffling to the bathroom hips, legs, back so painful, I read about the rosuvastatin side NOW-2wks- walking 6 kms, running on a mini-tramp 40 mins, swimming 90 laps of a pool -25strokes across- I m effortlessly gliding, no cramps, enjoying experience.

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