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4 Polysomnography conducted in subjects with moderate to severe primary RLS and associated sleep disturbance demonstrated that treatment with gabapentin enacarbil 1, 00 mg significantly reduced the wake time during sleep and PLM associated with arousal per hour of sleep compared with placebo. 6 Gabapentin enacarbil 1, 00 mg also significantly increased the time in slow-wave sleep compared with placebo.and hyperkinesia.
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It was negative in the Ames test and the In vitro HGPRT forward mutation assay in Chinese hamster lung cells; it did not produce significant increases in chromosomal aberrations in the in vitro Chinese hamster lung cell assay; it was negative in the in vivo chromosomal aberration assay and in the in vivo micronucleus can gabapentin cause missed periods in Chinese hamster bone marrow; it was negative in the in vivo mouse micronucleus assay; and it did not induce unscheduled DNA synthesis in hepatocytes from rats given gabapentin.Seizure control is very important during pregnancy, and having a seizure could harm both mother and baby.
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He has a Doc appt. in the morning to be evaluated before they will refill it.However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
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