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If the cell count has not decreased after 6 months, or if the CSF cell count or protein is not normal after 2 years, retreatment should be considered. Limited data suggest that in immunocompetent persons and persons with HIV infection on highly active antiretroviral therapy, normalization of the serum RPR titer predicts doxycycline and weight loss of CSF parameters following neurosyphilis treatment 425 Limited data suggest that ceftriaxone 2 g daily either IM or IV for 10 14 days can be used as an alternative treatment for persons with neurosyphilis.Taking doxycycline when pregnant can slow down bone growth and stain the teeth of the developing foetus.

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