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|Pronunciation||/ ˌ ɛ s t r ə ˈ d aɪ oʊ l / ES -trə- DY -ohl  |
|Pregnancy category||AU: B1 US: X (Contraindicated)|
|Routes of administration||• By mouth (tablet) • Sublingual (tablet) • Intranasal (nasal spray) • Transdermal (patch, gel, cream, emulsion, spray) • Vaginal (tablet, cream, suppository, insert, ring) • IM injection (oil solution) • SC injection (aq. soln.) • Subcutaneous implant|
|ATC code||G03CA03 ( WHO )|
|Legal status||AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)|
|Bioavailability||Oral: <5%  IM: 100% |
|Protein binding||~98%:   • Albumin: 60% • SHBG: 38% • Free: 2%|
|Metabolism||Liver (via hydroxylation, sulfation, glucuronidation)|
|Metabolites||Major (90%):  • Estrone • Estrone sulfate • Estrone glucuronide • Estradiol glucuronide|
|Elimination half-life||Oral: 13–20 hours  Sublingual: 8–18 hours  Transdermal (gel): 37 hours  IM (as EV): 4–5 days  IM (as EC): 8–10 days  IV (as E2): 1–2 hours |
|Excretion||Urine: 54%  Feces: 6% |
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- Climaval 2 mg
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|Estrace alternative names||absorlent, activella, activelle, aerodiol, agofollin, akrofolline, alcis, allurene, alora, angeliq, angemin, armonil, avaden, avadène, avixis, bedol, benzo-ginestryl, bisteron, bothermon, calidiol, cliane, climaderm, climagest, climara, climaval, climen, climene, climesse, climodien, clinorette, clionara, cliovelle, combipatch, compudose, convadien, crinohermal, cutanum, cyclacur, cyclo-progynova, cyclocur, cyclofemina, delestrogen, délidose, depo-estradiol, dermestril, despamen, di-pro, dihormon, dilena, dimenformon, divigel, divina, diviplus, diviseg, diviseq, divitren, diviva, duofemme, duokliman, elestrin, elleste solo, emmenovis, enadiol, encore, endomina, ep hormone, ephelia, epiestrol, esclima, esjin, esprasone, essventia, estalis, estolmon, estopause, estracomb, estracomb tts, estracombi, estraderm, estradiol cypionate, estradiolo, estradiolum, estradot, estragest tts, estrahexal, estramon, estrana, estranova e, estrapatch, estrasorb, estrena, estreva, estrifam, estrimax, estring, estro-pause, estrodose, estrofem, estroffik, estrogel, estronorm, esumon, etrosteron, eutocol, evamist, eviana, evopad, evore|
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In: Wein AJ, Kavoussi LR, Partin AW, Peters CA, eds.5.
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