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Clinical data
Pronunciation/ ˌ ɛ s t r ə ˈ d aɪ oʊ l / ES -trə- DY -ohl [1] [2]
Trade namesNumerous
Pregnancy categoryAU: B1 US: X (Contraindicated)
Routes of administration• By mouth (tablet) • Sublingual (tablet) • Intranasal (nasal spray) • Transdermal (patch, gel, cream, emulsion, spray) • Vaginal (tablet, cream, suppository, insert, ring) • IM injection (oil solution) • SC injection (aq. soln.) • Subcutaneous implant
Drug classEstrogen
ATC codeG03CA03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityOral: <5% [3] IM: 100% [4]
Protein binding~98%: [3] [5] • Albumin: 60% • SHBG: 38% • Free: 2%
MetabolismLiver (via hydroxylation, sulfation, glucuronidation)
MetabolitesMajor (90%): [3] • Estrone • Estrone sulfate • Estrone glucuronide • Estradiol glucuronide
Elimination half-lifeOral: 13–20 hours [3] Sublingual: 8–18 hours [6] Transdermal (gel): 37 hours [7] IM (as EV): 4–5 days [4] IM (as EC): 8–10 days [8] IV (as E2): 1–2 hours [4]
ExcretionUrine: 54% [3] Feces: 6% [3]

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Estrace product names drug:
  1. Absorlent 2 mg
  2. Activella 2 mg
  3. Activelle 1 mg
  4. Aerodiol 2 mg
  5. Agofollin 1 mg
  6. Akrofolline 1 mg
  7. Alcis 2 mg
  8. Allurene 2 mg
  9. Alora 2 mg
  10. Angeliq 1 mg
  11. Angemin 2 mg
  12. Armonil 1 mg
  13. Avaden 1 mg
  14. Avadène 2 mg
  15. Avixis 2 mg
  16. Bedol 2 mg
  17. Benzo-ginestryl 1 mg
  18. Bisteron 1 mg
  19. Bothermon 2 mg
  20. Calidiol 1 mg
  21. Cliane 2 mg
  22. Climaderm 2 mg
  23. Climagest 1 mg
  24. Climara 2 mg
  25. Climaval 2 mg

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Estrace information
Drug name Estrace
Estrace alternative namesabsorlent, activella, activelle, aerodiol, agofollin, akrofolline, alcis, allurene, alora, angeliq, angemin, armonil, avaden, avadène, avixis, bedol, benzo-ginestryl, bisteron, bothermon, calidiol, cliane, climaderm, climagest, climara, climaval, climen, climene, climesse, climodien, clinorette, clionara, cliovelle, combipatch, compudose, convadien, crinohermal, cutanum, cyclacur, cyclo-progynova, cyclocur, cyclofemina, delestrogen, délidose, depo-estradiol, dermestril, despamen, di-pro, dihormon, dilena, dimenformon, divigel, divina, diviplus, diviseg, diviseq, divitren, diviva, duofemme, duokliman, elestrin, elleste solo, emmenovis, enadiol, encore, endomina, ep hormone, ephelia, epiestrol, esclima, esjin, esprasone, essventia, estalis, estolmon, estopause, estracomb, estracomb tts, estracombi, estraderm, estradiol cypionate, estradiolo, estradiolum, estradot, estragest tts, estrahexal, estramon, estrana, estranova e, estrapatch, estrasorb, estrena, estreva, estrifam, estrimax, estring, estro-pause, estrodose, estrofem, estroffik, estrogel, estronorm, esumon, etrosteron, eutocol, evamist, eviana, evopad, evore
Active substanceestradiol
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