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Clinical data
Pronunciation/ ˌ d aɪ f ɛ n ˈ h aɪ d r ə m iː n /
Trade namesBenadryl, Unisom, Sominex, others
Pregnancy categoryAU: A US: B (No risk in non-human studies)
Dependence liabilityVery low
Routes of administrationBy mouth, intramuscular injection, intravenous, topical, rectal
ATC codeD04AA32 ( WHO ) D04AA33 ( WHO ), R06AA02 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) US: OTC
Pharmacokinetic data
Bioavailability40–60% [2]
Protein binding98–99%
MetabolismLiver (CYP2D6 (80%), CYP3A4 (10%)) [1]
Elimination half-lifeRange: 2.4–13.5 hrs [3] [2] [4]
ExcretionUrine: 94% [5] Feces: 6% [5]

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First-generation antihistamines ( diphenhydramine, etc) usually work as well as second generation antihistamines for allergic rhinitis. But drowsiness and dry ...: how to choose an antihistamine - Pharmacist's Letter

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There may diphenhydramine clonazepam special precautions for using antihistamines if you have: Increased pressure in the eye glaucoma nlarged prostate or problems passing urineEpilepsyOveractive thyroidHeart disease or high blood pressureDiabetes Diphenhydramine clonazepam effects of antihistamines may include: DizzinessDry mouthDrowsinessFeeling nervous, excited, or irritableChanges in vision, such as blurry visionDecreased appetite Corren J, Baroody FM, Pawankar R.

Allergic and nonallergic rhinitis. Arit%depmssant: _. AwitriptyZine. BCL. 25Gig. Antidiabetic: Tolburanide'. 5mng. Ar!tihistamine: Diphenhydramine. 50 ms*. Ataravi cs : ChlBiqliazepoxide. The structural formula is as follows: Diphenhydramine hydrochloride is an antihistamine with anticholinergic drying and sedative side effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells.

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For use in parkinsonism, when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents; mild cases of parkinsonism in other age diphenhydramine clonazepam, and in other cases of parkinsonism in combination with centrally acting anticholinergic agents.This drug diphenhydramine clonazepam often cause excitement in young children instead of drowsiness.

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