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Clinical data
Trade namesCiloxan, Cipro, Neofloxin, others
License dataUS   FDA: Ciprofloxacin
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationBy mouth, intravenous, topical (ear drops, eye drops)
Drug classFluoroquinolone
ATC codeJ01MA02 ( WHO ) S01AE03 ( WHO ) S02AA15 ( WHO ) S03AA07 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability70% [1]
Protein binding30% [1]
MetabolismLiver (incl. CYP1A2)
Elimination half-life3.5 hours [1]

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    G/dayNausea 3% Abdominal pain 2% Diarrhea 2% adults; 5% children Increased aminotransferase levels 2% Vomiting 1% adults; 5% children Headache 1% Increased serum creatinine 1% Rash 2% Restlessness 1% Acidosis Allergic reaction Angina pectoris Anorexia Arthralgia Ataxia Back pain Bad taste Blurred vision Breast pain Bronchospasm Diplopia Dizziness Drowsiness Dysphagia Dyspnea Flushing Foot pain Hallucinations Hiccups Cipro 750 Hypotension Insomnia Irritability Joint stiffness Lethargy Migraine Nephritis Nightmares Oral candidiasis Palpitation Photosensitivity Polyuria Syncope Tachycardia Tinnitus Tremor Urinary retention Vaginitis Acute generalized exanthematous pustulosis AGEP erythema multiforme, exfoliative dermatitis, fixed eruption, photosensitivity/phototoxicity reaction Agitation, confusion, delirium Agranulocytosis, albuminuria, serum cholesterol and TG elevations, blood glucose disturbances, hemolytic anemia, marrow depression life threatening pancytopenia life threatening or fatal outcome potassium elevation serum Anaphylactic reactions including life-threatening anaphylactic shock serum sickness like reaction, Stevens-Johnson syndrome Anosmia, hypesthesia Constipation, dyspepsia, dysphagia, flatulence, hepatic failure including fatal cases hepatic necrosis, jaundice, pancreatitis Hypertonia, hypotension postural increased INR in patients treated with Vitamin K antagonists QT cipro 750, torsade de pointes, ventricular arrhythmia Methemoglobinemia Myasthenia, exacerbation of myasthenia gravis, myoclonus, nystagmus, cipro 750 neuropathy that may be irreversible, phenytoin alteration serum polyneuropathy, psychosis Myalgia, tendinitis, tendon rupture, toxic epidermal necrolysis Lyell s Syndrome twitching Infections: Candiduria, vaginal candidiasis, moniliasis oral, gastrointestinal, vaginal pseudomembranous colitis Renal calculi Vasculitis Aortic aneurysm and dissection Fluoroquinolones have been associated with disabling cipro 750 potentially irreversible serious adverse reactions that have occurred together including: tendinitis and tendon rupture, peripheral neuropathy, and central nervous system CNS effectsDiscontinue treatment immediately and avoid use of systemic fluoroquinolones in patients who experience any of these serious adverse reactionsMay exacerbate muscle weakness in patients with myasthenia gravis; 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